At Herbicure, our research aims to find solutions in areas where significant unmet medical need exists, specifically research aimed at identifying medicinal plants and non-antimicrobial chemicals as safe and effective agents to prevent and treat infections caused by resistant organisms.
Our research is aimed at identifying solutions against the highly invasive
and toxigenic aerobic Gram-negative bacteria
; solutions against the problems of MDR in Pseudomonas aeruginosa
and to find answers to the problem of multidrug and extensively drug resistant Mycobacterium tuberculosis
We understand that there exists significant antimicrobial action in a large number of pharmacologically diverse categories of compounds designated as “non-antibiotics
”. Moreover, we understand that some of these “non-antibiotics
” act synergistically with other conventional antibiotics rendering initially resistant bacteria susceptible.
Our scientific team led by Life Time Achievement Award Winner, Professor Dr.Sujata Ghosh Dastidar, are well equipped with techniques for carrying out research in in vitro and in vivo models in bacteriology and in mycology.
We have made some early investigations into the mechanisms of resistance and activities of some lead compounds to find answers to problems related to highly invasive and toxigenic aerobic Gram-negative bacteria, particularly the MDR in Pseudomonas aeruginosa.
We have especial interest in area of multidrug and extensively drug resistant Mycobacteriumtuberculosis research; where, we have also made significant advancement in decontamination studies and in studies to identify and validate rapid growth and isolation techniques for testing drug sensitivity in mycobacteria.
In some of our early breakthroughs, we have investigated the antimicrobial effect of flavonoids in various species of resistant bacteria.
We have exploited the stereo-chemical aspects - enantiomers and racemic forms of compounds to establish some of the yet unknown properties in the field of anti-microbial discovery.
We have undertaken studies to discover the synergism between different compounds, and to discover early proof of synergism between compounds against some virulent and multidrug resistant organisms.
We have also made significant progress in identifying anti-oxidant
protective properties of some plant derived products against ultraviolet ray damage to the skin.
In collaboration with Southern Danish University, Odense, Denmark and University of Copenhagen, we have investigated properties of chemical compounds against mainly the resistant gram positive and gram negative bacteria.
Our key collaborators in anti-microbial research includes:
Please read our archive for our published research papers.
- Division of Molecular and Human Genetics, Indian Institute of Chemical Biology, Kolkata
- Department of Physics, Jadavpur University, Kolkata
- Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata
- Drug development/Diagnostics and Biotechnology Division, Indian Institute of Chemical Biology, Kolkata
- Division of Bacteriology, National Institute of Cholera and Enteric Diseases, Kolkata
- Department of Botany, University of Calcutta
- Bengal School of Technology, Chinsurah, West Bengal